Author: tio

  • Smart Drugs Are Here

    There is a quiet revolution going on. While so much media attention is being spent on debating the risks vs benefits of raw milk, the latest outrages from the systematic dismantling of quality science at the CDC and other federal agencies, and by the tsunami of terrible medical science being pushed on social media, science-based medicine marches on. Public awareness of recent […]

    The post Smart Drugs Are Here first appeared on Science-Based Medicine.

  • The Kingpin Fallacy: What happens when you take out the leader of a Mexican Cartel?

    A day after the Mexican military killed Nemesio “El Mencho” Oseguera Cervantes, the leader of one of the country’s most powerful drug cartels, U.S. President Donald Trump claimed credit for his administration.

    “We’ve also taken down one of the most sinister cartel kingpins of all — you saw that yesterday,” Trump told Congress on February 23, 2026.

    Months of intense pressure including tariff threats had borne fruit: a Mexican special forces operation supported by U.S. intelligence resulted in a high-profile political win for both Trump and his Mexican counterpart, President Claudia Sheinbaum.

    But if the study of the U.S. drug war in Latin America reveals anything, it’s that killing or capturing cartel bosses — known as the kingpin strategy — fails to break drug supply chains. That’s because backers of the strategy fundamentally misunderstand the character of modern organized crime groups.

    The removal of a cartel boss like El Mencho often results in what researchers describe as the “hydra effect,” a reference to the Greek mythological hero Heracles’ difficulty in slaying the hydra, a venomous serpent. 

    For every head Heracles cut off, two new ones sprouted from the wound.

    “It’s very much the American narrative that organized crime groups are pyramidal organizations led by a supreme leader who controls everything,” said Adrián López Ortiz, director general of the Sinaloa newspaper Noreste. 

    Modern organized crime behaves more like a network, or grand spiderweb, he said.

    Despite Mexican authorities taking out dozens of cartel leaders since the drug war began in 2006 — often at the behest of, under pressure from, or in coordination with their U.S. counterparts — the street price and purity of drugs like cocaine and methamphetamine in the U.S. has remained relatively stable or fallen.

    Drug overdose deaths — a crude but important metric of drug use in the U.S. — saw a decade-long rise from 2014, according to the U.S. Drug Enforcement Agency (DEA).

    Most recently, several different interventions, including a supply-side disruption of precursor chemicals, appear to have reversed the trend, pointing to a more effective set of policies.

    “As far as the impact on trafficking goes, the kingpin strategy is largely symbolic,” said Genevieve Kotarska, an associate fellow at the Royal United Services Institute, a U.K.-based security think tank.

    Meanwhile, the relative stability provided by powerful cartels, known as “pax mafiosa,” is often replaced by the violent chaos of organizations breaking up into smaller groups. They become more violent as they compete over strategic trafficking routes and local rackets, security analysts say.

    “Pax mafiosa is the sort of relative appearance of peace that can exist under an organized criminal group, but it requires a level of stability and strong leadership that the kingpin strategy inherently undermines,” Kotarska told OCCRP.

    Absent a smooth handover of power, groups splinter and violence is unleashed.

    “The strategy of extracting and capturing leaders has only served to justify government strategies and reduce geopolitical tension,” said Darwin Franco Migues, the general coordinator of Jalisco-based investigative journalism platform ZonaDocs.

    Removing a leader doesn’t work, because the structure remains untouched, Franco said.

    “It is clear that it is a useless tool for dismantling criminal groups or reducing their control over communities,” said Catalina Niño, a Latin America security expert at the Friedrich-Ebert-Stiftung, a German think tank.

    “It has been pushed because it is easy to sell to a public that generally demands a heavy-handed response, and in that sense, it yields political gains.”

    To better understand what happens when a cartel leader is taken out, OCCRP examined the data, and asked Mexican journalists, regional analysts, and a Colombian former presidential advisor to explain how this scenario unfolds.

    Rise in Homicides

    In the hours after El Mencho’s killing, hundreds of burning roadblocks were erected across the country, creating a sense of national panic. 

    But in the days and weeks since, relative calm has returned to Jalisco.

    “There’s this tense calm, in which the government is trying to maintain the impression that everything is normal,” said Franco.

    “But what people are actually experiencing is that they’re waiting for something to happen.”

    Research suggests the sense of foreboding is justified.

    A 2015 research paper by the Institute for the Study of Labor Economics, a German non profit, examined the effects of the kingpin strategy and included an analysis of homicide rates in Mexico. Researchers found that the capture of a leader of a drug trafficking organisation in a municipality increases its homicide rate by 80 percent, and that this effect persists for at least twelve months.

    Examples abound.

    When Mexican President Felipe Calderón launched his so-called war on drugs in December 2006, the Sinaloa Cartel was in an alliance with another drug trafficking group, the Beltrán-Leyva Cartel.

    Calderon’s first “kingpin” arrest came in January 2008, with the detention of Alfredo Beltrán Leyva, a senior figure in the Beltrán-Leyva cartel.

    His detention led to the rupture of the alliance, a bloody conflict between the two groups, and an immediate spike in the national homicide rate, according to the NBER study.

    From that month on, murder rates continued to climb, and by the end of 2010 were 150 percent higher than they had been before the government launched the drug war, the study shows.

    The same trend was observed after Eduardo Arellano-Felix, leader of the Tijuana Cartel, was arrested in Tijuana, Baja California state, in October 2008. His cartel split into two rival factions, leading to a rise in local homicides, according to data in the study.

    Rubin Martin, a seasoned independent journalist from the Jalisco state recalls how the death of Ignacio “Nacho” Coronel Villareal, a founder of the Sinaloa Cartel in July 2010, also led to a period of intense unrest.

    “The death of Ignacio Coronel involved a restructuring of the companies and of the criminal economy here in Jalisco, and what we saw was truly a period of intensification of violence,” Martín said.

    “We began to see bodies in bags, people murdered with a message written on a piece of cardboard pinned to their chest, or with their testicles or penis stuck into their mouth to send a message of violence. This [was] performative violence.”

    In total, the Institute for the Study of Labor Economics paper estimated that kingpin captures led to an additional 11,626 homicides in Mexico between 2007 and 2015.

    “The effects of these kingpin captures can explain 36 percent of the 130 percent increase in the homicide rate (or approximately a quarter) between 2006 and 2010,” the study found.

    Splintering Organizations

    As the Mexican government captured or killed more leaders, other alliances and major cartels like Los Zetas, La Familia Michoacana, and the Gulf Cartel continued to fracture into smaller groups. 

    In other words, instead of defeating criminal groups, the kingpin strategy multiplied them. 

    In the decade after 2010, the number of criminal groups in Mexico exploded from 76 to 205, according to an analysis by the International Crisis Group, which developed a dataset of criminal groups by drawing on the country’s narcoblogs.

    “Crisis Group’s data show a clear correlation between the number of groups present in a municipality and the average per capita murder rate,” the ICG wrote in a report. 

    “Violence continues to increase broadly in step with the number of additional groups.”

    Jane Esberg, assistant professor of political science at the University of Pennsylvania, put together the ICG analysis.

    “One of the major causes of violence in criminal conflict is turf wars and contestation between criminal groups,” Esberg told OCCRP.

    “When a single group is in charge, it deters weaker challengers, who might consider their odds pretty bad. That’s not to say strong criminal groups don’t cause their own problems, but as a general rule there is often less violence when control over a territory isn’t contested.”

    It’s a phenomenon that’s repeated itself in the three decades since the DEA first developed the kingpin strategy to confront Colombian drug trafficking networks in the early 1990s. 

    In December 1993, police killed Pablo Escobar, the leader of Colombia’s Medellín Cartel. Two years later, they arrested the two brothers leading the Cali Cartel, who had become the dominant trafficking organization in Colombia following Escobar’s death.

    “The organizations immediately began to fight over whatever they wanted and ended up splitting,” said Hugo Acero Velásquez, a former presidential advisor during the peace accords in that era, and the former secretary of security for Bogotá. 

    “We went from personal organizations led by one person, a family or a specific clan, to highly organized corporations with many heads,” Acero said.

    This approach has failed to dent long term cocaine production, which increased around 2,800 percent to 2,664 metric tons in 2023, the latest year data is available, up from an estimated 92 metric tons in 1990, according to the United Nations Office on Drugs and Crime (UNODC). 

    Similarly in Mexico, the approach has yet to break the supply chains funneling narcotics north to the U.S..

    The Monitoring and Support Project for the Global Illicit Flows Programme, a project run by RUSI Europe in partnership with the European Union, reported last year that the “removal of high-level criminal actors, while important, appears to have limited impact on the market overall or supply trends, beyond displacement of commodity flow routes.”

    Makeshift Crematoriums

    As criminal groups have fragmented, the type of violence has also evolved alongside the way the government reports it.

    When Franco, the ZonaDocs coordinator, moved to Jalisco’s state capital Guadalajara in 2008, he didn’t feel the level of crime. That changed in 2010, he said.

    That year, the death of Sinaloa cartel leader Coronel, and the resulting crumbling of that group’s alliance with the Milenio Cartel triggered a bout of executions, but also the rise in a less visible kind of violence: kidnappings and forced disappearances.

    “It was in that period that the disappearances of people in Jalisco began to grow, until we arrived to where we are today, which is the capital of disappearances in all Mexico,” said Martín, the other journalist in Jalisco.

    “Even though the areas, neighborhoods, times, and the modus operandi are known, there hasn’t been any real action by the authorities to reduce them.”

    Last year a collective of citizens looking for missing relatives found human remains, piles of clothes, hundreds of shoes, ashes and alleged makeshift crematoriums at a ranch turned forced labour camp in Jalisco, which the attorney general said was controlled by people linked to El Mencho’s CJNG. 

    Local authorities had previously secured the ranch without cataloging or successfully investigating the remains.

    To complicate things further, in recent years the government has begun to reclassify many intentional murders under other categories.

    Security analysts and human rights organizations say this has created a statistical mirage of success, with the numbers “massaged” to artificially lower the homicide rate for political gain.

    Although official murder rates in Jalisco between 2024 and 2025 actually fell by around one third, manslaughter and femicides each saw increases of 7.6 and 3.2 percent, respectively, according to a report by Mexico’s Ibero-American University. 

    Meanwhile, disappearances exploded by 231%.

    Following the rupture within the Sinaloa Cartel, a similar pattern is now repeating in that state.

    “[In 2011], we had barely any disappeared people, and now we have more disappearances than homicides,” said López from newspaper Noreste. 

    In Sinaloa, for the year 2025, reports of missing persons overtook homicides, reaching approximately 2,400, according to an analysis by México Evalúa, a think tank.

    López also points to a sharp rise in other crimes, such as car theft, robberies, rape and arson, as well as the displacement of citizens by the ensuing territorial violence.

    “We have many rural zones, […] where they have completely abandoned villages because the people were displaced,” López said. “They’ve become ghost towns. They’re in complete dispute between the factions.”

    Ultimately, the drug war’s focus on kingpins rests on a mischaracterization of these groups, he said.

    “Every time that you take a node out, those relations reconfigure themselves.”

    Paradoxically, until his killing, El Mencho had actually benefited from the kingpin strategy as various rivals were removed by security forces and he was able to consolidate power, said Kotarska from the RUSI think tank.

    “One of the things that we’ve seen historically and contemporarily in Mexico and elsewhere is the links between cartels and political and economic elites. The kingpin strategy does very little to undermine those.”

    The enduring question for Mexico is not just who will take over El Mencho’s business, but why the state fails to tackle the network of elites supporting it.

  • Breaking the Gaza aid bottleneck: 106-tonne delivery arrives via new sea route

    The World Health Organization (WHO) has facilitated the delivery of some 106 metric tonnes of lifesaving nutrition supplies to the Gaza Strip – the first shipment via a mechanism to deliver aid by sea, in line with a UN Security Council resolution and amid the ongoing war in the Middle East. 
  • Middle East war: UN’s Türk decries ‘severe restrictions’ on free speech

    From Iran to multiple nations in the Gulf and the wider Middle East, around 3,000 people have reportedly been arrested in the first month of the ongoing war across the region, sparking alarm over free speech restrictions and state repression.
  • Women leaders unite to advance gender equality, defend multilateralism amid growing global pushback

    The Secretary-General’s commitment towards women leadership in the United Nations was recognized at a pivotal moment marked by global uncertainty, economic volatility and increasing pressure on hard-won rights.
  • PRO ASYL

    PRO ASYL is Germany’s largest pro immigration advocacy organization. Founded in 1986 by protestant pastor Jürgen Micksch, Catholic priest Herbert Leuninger and others, the organization has over 25.000 members and an annual budget of more than €5,800,000 (as of 2022). It supports asylum in Germany, in Europe and worldwide.

  • A Century of Colonial Tariffs

    In 1920, while the United States still numbered 48, Congress passed a law to protect American maritime shipping companies from foreign competition. Known as the Jones Act, the law required that any transport of goods between U.S. ports be performed by ships owned, built, and crewed by U.S. citizens. Foreign vessels could carry goods into or out of the United States, but not between ports within…

    Source

  • Pluralistic: Trumpismo vs minilateralism (01 Apr 2026)

    Today’s links



    A US $100 bill. Benjamin Franklin's face has been replaced with an orange blur surmounted by yellow candy-floss hair. The '100s' have been altered to read '000' and the 'ONE HUNDRED' now reads 'NONE HUNDRED.' The Secretary of the Treasury's signature has been replaced with Trump's signature. The series of the bill reads '47.'

    Trumpismo vs minilateralism (permalink)

    As November Kelly has pointed out, the weirdest thing about Trumpismo is how the man seethes and rails against a game that is thoroughly rigged in America’s favor, because he resents having to pretend to play the game at all:

    https://pluralistic.net/2026/01/26/i-dont-want/#your-greenback-dollar

    Before Trump, the deal was that everyone would pretend that we had a “rules-based international order” in which every country got a fair deal, even as America cheated like hell and sucked the world dry. It’s really impossible to overstate how advantageous this was to America. By pretending to be a neutral interchange spot for transoceanic fiber cables, it got to spy on the world’s internet traffic:

    https://pluralistic.net/2025/11/26/difficult-multipolarism/#eurostack

    By pretending to have a neutral currency, it got to exercise “dollar dominance” through which the nations of the world sent America the things they dug out of the ground or built in their factories, in exchange for America making small adjustments to a spreadsheet at the Federal Reserve. And by pretending its tech exports were neutral platforms, America got to raid the world’s private data and bank accounts, spying and looting to its heart’s content.

    When Trump kicked off his campaign of incontinent belligerence – putting tariffs on the exports of countries populated only by penguins, trying to steal Greenland – it became impossible for the world’s leaders to carry on this pretense.

    This led to Canadian Prime Minister Mark Carney – the world’s most Davos man – standing up at this year’s World Economic Forum to denounce the whole post-war settlement as a bullshit arrangement, announcing that we were in a period of “rupture” and promising a new world of “variable geometry” in which “middle powers” would exist in overlapping webs of alliances, without the USA:

    https://pluralistic.net/2026/01/27/i-want-to-do-it/#now-make-me-do-it

    Now, thanks to Trump’s America First agenda, America’s many advantages are collapsing. The dollar is in retreat, with Ethiopia revaluing its national debt in Chinese renminbi:

    https://fidelpost.com/ethiopia-and-china-move-toward-final-stage-of-debt-restructuring-agreement/

    Even worse: Trump’s disastrous war of choice in Iran is heading for a humiliating defeat for the dollar, with Iran announcing that any peace deal will require a $2m/ship toll to pass through the Strait of Hormuz, a toll they’re already collecting, payable only in renminbi:

    https://www.nbcnews.com/world/iran/irans-tehran-toll-booth-forces-tankers-pay-millions-leave-strait-hormu-rcna265258

    (I really hope Trump’s plan to rename it the “Strait of Trump” catches on, so that his name in invoked with every tanker that traverses the strait, weakening the dollar and America’s power – a very fitting legacy.)

    For the past quarter-century, I’ve fought the US Trade Representative in various international fora, as the USTR piled all kinds of conditions America’s trading partners that made it impossible to pursue any kind of technological sovereignty:

    https://pluralistic.net/2026/01/01/39c3/#the-new-coalition

    Every now and then, I think about how furious the USTR must be, watching Trump blunder through all the subtle traps they wove around the planet.

    Take the “digital trade agenda,” a set of policies that the US has made its top priority for a decade. Countries that succumbed to the digital trade agenda had to agree not to pursue “data localization” (rules that ban companies from moving or storing data about the people of your country outside of its borders), and they had to agree to duty-free status for digital exports like apps, music, games, ebooks and videos.

    Today, the digital trade agenda is in tatters. Data localization is the top priority, with projects like the Eurostack and the European Digital Infrastructure Consortium breaking all land-speed records to build on-shore apps and data-centers that will keep data out of the hands of American companies and the American government:

    https://digital-strategy.ec.europa.eu/en/policies/edic

    And this week, duty-free status for digital assets hit the skids when a meeting of the World Trade Organization saw America’s demands for a 10-year renewal of a global deal fail because Brazil wouldn’t agree to it. Brazil has good reasons to mistrust the digital trade agenda, after Trump and Microsoft colluded to shut down a high court judge’s online life in retaliation for passing sentence on the Trump-allied former dictator, Jair Bolsonaro:

    https://home.treasury.gov/news/press-releases/sb0211

    Brazil blocked the 10-year renewal of the duty-free status of digital exports, worldwide. In its place, the US got a two-year renewal – meaning that US companies’ ability to export their digital products after 2028 will depend on whatever Trump does in the next two years, a period during which we know Trump is going to be a raging asshole (assuming he doesn’t have a stroke first).

    Even more interesting: Brazil struck a “minilateral” digital duty-free deal with 66 non-US countries, including Canada and the EU:

    https://www.csmonitor.com/Editorials/the-monitors-view/2026/0331/EU-and-Canada-lean-into-a-new-world-role?icid=rss

    Now, the US is a powerhouse exporter of digital goods, and has been since the start. This was such a given that in Neal Stephenson’s 1992 cyberpunk classic Snow Crash, Stephenson imagined a future where the US had all but collapsed, save for the three things it did better than anyone else in the world: “music, movies and microcode”:

    https://www.gdcvault.com/play/1015147/Music-Movies-Microcode-High-Speed

    Today, America’s media and software industries are dying, and Trump is holding a pillow over their faces. He stole Tiktok and gave it to his buddy Larry Ellison, whose failson’s acquisition and merger of two of the five remaining studios Trump also waved through:

    https://pluralistic.net/2026/02/28/golden-mean/#reality-based-community

    Game studios are ensloppifying their flagship products, alienating their most ardent customers, and are laying off thousands of programmers and artists following incestuous mergers that leave them hopelessly bloated:

    https://www.blog.udonis.co/mobile-marketing/mobile-games/activision-blizzard-layoffs

    Meanwhile, there’s a global cultural market that’s sweeping away American media: from K-pop (and K-zombies) to Heated Rivalry to Brazil funk:

    https://en.wikipedia.org/wiki/Funk_carioca

    Now, thanks to Trump, there are just a couple of years until America’s wilting cultural exports will face high tariffs from markets where international media is surging.

    This is how the American century ends: not with a bang, but with a Trump.


    Hey look at this (permalink)



    A shelf of leatherbound history books with a gilt-stamped series title, 'The World's Famous Events.'

    Object permanence (permalink)

    #25yrsago My new sigfile https://memex.craphound.com/2001/03/30/

    #20yrsago TBL’s “The Future of the Web” https://web.archive.org/web/20070706130940/http://webcast.oii.ox.ac.uk/download/oii/20060314_139/20060314_139.mp3

    #20yrsago Bruce Sterling’s bumper stickers https://web.archive.org/web/20060401010820/https://www.bumperactive.com/archives/000685.jsp

    #15yrsago Kinect makes UAV even more autonomous https://www.suasnews.com/2011/03/mit-slam-quad-using-kinect/

    #15yrsago This frozen yogurt store offers the best discounts around https://memex.craphound.com/2016/03/30/this-frozen-yogurt-store-offers-the-best-discounts-around/

    #10yrsago Amazing fan-made Wonder Woman sweater pattern to download and knit https://www.ravelry.com/patterns/library/wonder-woman-2

    #10yrsago Automated drug cabinets have 1400+ critical vulns that will never be patched https://www.helpnetsecurity.com/2016/03/30/1400-flaws-automated-medical-supply-system/

    #10yrsago Playable records laser-etched in cheese, eggplant and ham https://web.archive.org/web/20160323075536/http://www.thevinylfactory.com/vinyl-factory-news/matthew-herbert-tortilla-edible-vinyl/

    #10yrsago Up to half of the Americans killed by police have a disability https://www.theguardian.com/society/2016/mar/29/media-must-report-police-violence-towards-disabled-people

    #10yrsago Judge says Citibank’s law-school loan isn’t “student debt” and can be discharged in bankruptcy https://abcnews.com/Business/judges-ruling-law-school-grads-debt-signal-seismic/story?id=37981518

    #10yrsago How a street artist pulled off a 50-building mural in Cairo’s garbage-collector district https://www.nytimes.com/2016/03/29/world/middleeast/cairo-mural-garbage.html

    #10yrsago CNBC’s secure password tutorial sent your password in the clear to 30 advertisers https://web.archive.org/web/20160331095151/https://motherboard.vice.com/read/cnbc-tried-and-massively-failed-to-teach-people-about-password-security

    #10yrsago How DRM would kill the next Netflix (and how the W3C could save it) https://www.eff.org/deeplinks/2016/03/interoperability-and-w3c-defending-future-present

    #5yrsago America needs a high-fiber broadband diet https://pluralistic.net/2021/03/30/fight-for-44/#slowpokes

    #5yrsago Minimum wage vs Wall Street bonuses https://pluralistic.net/2021/03/30/fight-for-44/#fight-for-44


    Upcoming appearances (permalink)

    A photo of me onstage, giving a speech, pounding the podium.



    A screenshot of me at my desk, doing a livecast.

    Recent appearances (permalink)



    A grid of my books with Will Stahle covers..

    Latest books (permalink)



    A cardboard book box with the Macmillan logo.

    Upcoming books (permalink)

    • “The Reverse-Centaur’s Guide to AI,” a short book about being a better AI critic, Farrar, Straus and Giroux, June 2026 (https://us.macmillan.com/books/9780374621568/thereversecentaursguidetolifeafterai/)
    • “Enshittification, Why Everything Suddenly Got Worse and What to Do About It” (the graphic novel), Firstsecond, 2026

    • “The Post-American Internet,” a geopolitical sequel of sorts to Enshittification, Farrar, Straus and Giroux, 2027

    • “Unauthorized Bread”: a middle-grades graphic novel adapted from my novella about refugees, toasters and DRM, FirstSecond, 2027

    • “The Memex Method,” Farrar, Straus, Giroux, 2027



    Colophon (permalink)

    Today’s top sources:

    Currently writing: “The Post-American Internet,” a sequel to “Enshittification,” about the better world the rest of us get to have now that Trump has torched America. First draft complete. Second draft underway.

    • “The Reverse Centaur’s Guide to AI,” a short book for Farrar, Straus and Giroux about being an effective AI critic. LEGAL REVIEW AND COPYEDIT COMPLETE.
    • “The Post-American Internet,” a short book about internet policy in the age of Trumpism. PLANNING.

    • A Little Brother short story about DIY insulin PLANNING


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  • My daughter has childhood dementia and may not live past 16

    Diagnosed just before her fourth birthday, Sophia, now 15, can no longer speak and cannot walk unaided.